Cathelicidins and innate defense against invasive bacterial infection

被引:67
作者
Nizet, V
Gallo, RL
机构
[1] Univ Calif San Diego, Dept Pediat, Div Infect Dis, San Diego, CA 92103 USA
[2] Univ Calif San Diego, Dept Pediat, Div Dermatol, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Med, Div Dermatol, San Diego, CA 92103 USA
[4] VA San Diego Healthcare Syst, San Diego, CA USA
关键词
D O I
10.1080/00365540310015629
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Cathelicidins are small cationic peptides that possess broad-spectrum antimicrobial activity. These gene-encoded 'natural antibiotics' are produced by several mammalian species on epithelial surfaces and within the granules of phagocytic cells. Since their discovery over a decade ago, cathelicidins have been speculated to function within the innate immune system, contributing to a first line of host defense against an array of microorganisms. Consequently, cathelicidins have captured the interest of basic investigators in the diverse fields of cell biology, immunology, protein chemistry and microbiology. A burgeoning body of experimental research now appears to confirm and extend the biological significance of these fascinating molecules. This article reviews the latest advances in the knowledge of cathelicidin antimicrobial peptides, with particular emphasis on their role in defense against invasive bacterial infection and associations with human disease conditions.
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收藏
页码:670 / 676
页数:7
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