Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells

被引：54

作者：

Ibrahim, AS

Filler, SG

Sanglard, D

Edwards, JE

Hube, B

机构：

[1] Univ Calif Los Angeles, Harbor Med Ctr, Div Infect Dis,Res & Educ Inst, St Johns Cardiovasc Res Ctr,Dept Med, Torrance, CA 90509 USA

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA

[3] CHU Vaudois, Inst Microbiol, CH-1011 Lausanne, Switzerland

[4] Univ Hamburg, Inst Allgemeine Bot, AMP 3, D-22609 Hamburg, Germany

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 06期

关键词：

D O I：

10.1128/IAI.66.6.3003-3005.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial cells.

引用

页码：3003 / 3005

页数：3

共 15 条

[1] EXPRESSION OF EXTRACELLULAR ACID PROTEINASE BY PROTEOLYTIC CANDIDA SPP DURING EXPERIMENTAL-INFECTION OF ORAL-MUCOSA [J].

BORG, M ;

RUCHEL, R .

INFECTION AND IMMUNITY, 1988, 56 (03) :626-631

[2] CHARACTERIZATION OF CANDIDA-ALBICANS EPIDERMOLYTIC PROTEASES AND THEIR ROLE IN YEAST-CELL ADHERENCE TO KERATINOCYTES [J].

ELMAGHRABI, EA ;

DIXON, DM ;

BURNETT, JW .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1990, 15 (03) :183-191

[3] PENETRATION AND DAMAGE OF ENDOTHELIAL-CELLS BY CANDIDA-ALBICANS [J].

FILLER, SG ;

SWERDLOFF, JN ;

HOBBS, C ;

LUCKETT, PM .

INFECTION AND IMMUNITY, 1995, 63 (03) :976-983

[4] Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells [J].

Filler, SG ;

Pfunder, AS ;

Spellberg, BJ ;

Spellberg, JP ;

Edwards, JE .

INFECTION AND IMMUNITY, 1996, 64 (07) :2609-2617

[5]

HILENSKI LL, 1986, J GEN MICROBIOL, V132, P1441

[6]

Hube B, 1996, Curr Top Med Mycol, V7, P55

[7] Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence [J].

Hube, B ;

Sanglard, D ;

Odds, FC ;

Hess, D ;

Monod, M ;

Schafer, W ;

Brown, AJP ;

Gow, NAR .

INFECTION AND IMMUNITY, 1997, 65 (09) :3529-3538

[8] EVIDENCE IMPLICATING PHOSPHOLIPASE AS A VIRULENCE FACTOR OF CANDIDA-ALBICANS [J].

IBRAHIM, AS ;

MIRBOD, F ;

FILLER, SG ;

BANNO, Y ;

COLE, GT ;

KITAJIMA, Y ;

EDWARDS, JE ;

NOZAWA, Y ;

GHANNOUM, MA .

INFECTION AND IMMUNITY, 1995, 63 (05) :1993-1998

[9] INTERFERON-GAMMA PROTECTS ENDOTHELIAL-CELLS FROM DAMAGE BY CANDIDA-ALBICANS [J].

IBRAHIM, AS ;

FILLER, SG ;

GHANNOUM, MA ;

EDWARDS, JE .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (06) :1467-1470

[10] ADHERENCE OF CANDIDA-ALBICANS TO ENDOTHELIAL-CELLS IS INHIBITED BY PROSTAGLANDIN I-2 [J].

KLOTZ, SA .

INFECTION AND IMMUNITY, 1994, 62 (04) :1497-1500

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