Variants in hepatocyte nuclear factor 4α gene promoter region and type 2 diabetes risk in Chinese

被引：9

作者：

Chen, Zhuo ^{[1
]}

Zhang, Di ^{[1
]}

Liu, Yun ^{[1
,3
]}

Zhou, Daizhan ^{[1
]}

Zhao, Teng ^{[1
]}

Yang, Yifeng ^{[1
]}

He, Lin ^{[1
,2
,3
]}

Xu, He ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China

[2] Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200031, Peoples R China

[3] Fudan Univ, Inst Biomed Sci, Shanghai 200031, Peoples R China

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 235卷 / 07期

基金：

中国国家自然科学基金;

关键词：

type; 2; diabetes; HNF4A; association; cholesterol; HDL; heterogeneity; FACTOR-4-ALPHA P2 PROMOTER; GENOME-WIDE SEARCH; SUSCEPTIBILITY LOCUS; UPSTREAM PROMOTER; CHROMOSOME; 20Q; ASSOCIATION; LINKAGE; POLYMORPHISMS; HNF-4-ALPHA; METABOLISM;

D O I：

10.1258/ebm.2010.010024

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

As a key regulator of insulin secretion and metabolism of glucose, cholesterol and fatty acid, hepatocyte nuclear factor 4 alpha (HNF4A) was suggested as a candidate gene for type 2 diabetes (T2D); however, no association study between HNF4A and T2D in the Chinese population has been conducted before. To address this issue, we evaluated the impact of the HNF4A variants (rs1884614 and rs2425637) on T2D and metabolic traits in 1912 unrelated patients and 2041 control subjects in the Chinese Han population. Our results suggested that no individual single nucleotide polymorphisms of HNF4A was significantly associated with T2D at either allele or genotype level. However, rs2425637 in the promoter region of HNF4A was found to have an effect on total cholesterol and high-density lipoprotein before multiple testing correction. To summarize, our investigation did not confirm the effects of HNF4A variants (rs1884614 and rs2425637) on T2D risk, but found that the risk HNF4A contributed to T2D might be population specific.

引用

页码：857 / 861

页数：5

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