Chemistry of hydrazinoalcohols and their heterocyclic derivatives.: Part 1.: Synthesis of hydrazinoalcohols

被引：36

作者：

Zalán, Z ^{[1
]}

Lázár, L ^{[1
]}

Fülöp, F ^{[1
]}

机构：

[1] Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary

来源：

CURRENT ORGANIC CHEMISTRY | 2005年 / 9卷 / 04期

关键词：

D O I：

10.2174/1385272053174949

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrazinoalcohols are versatile di- or trifunctional compounds with wide-ranging possibilities for application in organic synthesis. Numerous methods have been devised for the preparation of this family of compounds in recent decades. This review discusses the main pathways for the synthesis of hydrazinoalcohol derivatives, including epoxide ring-openings and nucleophilic substitutions by hydrazines, addition reactions to hydroxyhydrazones, hydrazine additions to olefinic bonds, electrophilic C- and N-amination reactions, cycloadditions, reductions of N-nitroso aminoalcohols and some unique procedures. The latest developments in these fields, involving both conventional and enzymatic catalytic methods of synthetic organic chemistry, allow the highly regio-, stereo- and enantioselective preparation of hydrazinoalcohol derivatives.

引用

页码：357 / 376

页数：20

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