Cutting edge: Restoration of the ability to generate CTL in mice immune to adenovirus by delivery of virus in a collagen-based matrix

被引:49
作者
Siemens, DR
Elzey, BD
Lubaroff, DM
Bohlken, C
Jensen, RJ
Swanson, AK
Ratliff, TL
机构
[1] Univ Iowa, Dept Urol, Ctr Canc, Iowa City, IA 52242 USA
[2] Vet Adm Med Ctr, Dept Urol, Iowa City, IA 52242 USA
[3] Vet Adm Med Ctr, Dept Microbiol, Iowa City, IA 52242 USA
[4] Vet Adm Med Ctr, Prostate Canc Res Grp, Iowa City, IA 52242 USA
[5] Vet Adm Med Ctr, Program Immunol, Iowa City, IA 52242 USA
关键词
D O I
10.4049/jimmunol.166.2.731
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Viruses are commonly used for the delivery of genes coding for tumor-associated Ags to elicit tumor-specific immune responses. The success of viral vectors has been limited in preclinical and clinical trials in part because of antiviral immunity, We investigated the ability of a collagen-based matrix (Gelfoam; Pharmacia and Upjohn, Kalamazoo, MI) to improve CTL activation by recombinant adenovirus. The data show that coinjection of Gelfoam with type 5 adenovirus recombinant for prostate-specific Ag (Ad5-PSA) enhanced CTL activation. Ad5-PSA priming in Gelfoam also abrogated the inhibitory effects of adenoviral immunity on CTL activation in mice naive to PSA but immune to adenovirus. Finally, Gelfoam enhanced immunization in a self-Ag model using type 5 adenovirus recombinant for membrane-bound OVA (Ad5-mOVA) in rat insulin promoter (RIP)-mOVA-transgenic mice. Thus, Gelfoam enhances CTL activation by recombinant viral vectors in a setting where preformed Ab to the virus is present and also in a tolerant self-Ag model.
引用
收藏
页码:731 / 735
页数:5
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