Noninvasive human rain stimulation

被引：628

作者：

Wagner, Timothy ^{[1
]}

Valero-Cabre, Antoni

Pascual-Leone, Alvaro

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Noninvas Brain Stimulat, Boston, MA 02215 USA

[2] Boston Univ, Sch Med, Dept Anat & Neurobiol, Lab Cerebral Dynam Plast & Rehab, Boston, MA 02218 USA

[3] Fdn Ophtalmol Rothschild, Dept Neurol, CNRS, LPNC,Unit ERT Treat Vis 5105, F-75019 Paris, France

[4] Univ Autonoma Barcelona, Inst Guttmann Rehab, E-08193 Barcelona, Spain

来源：

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING | 2007年 / 9卷

关键词：

TMS; tDCS; electromagnetism; neural networks; modeling; neurophysiology; neuromodulation; therapeutic applications; rehabilitation;

D O I：

10.1146/annurev.bioeng.9.061206.133100

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Noninvasive brain stimulation with transcranial mignetic stimulation (TMS) or transcranial direct current stimulation (tDCS) is valuable in research and has potential therapeutic applications in cognitive neuroscience, neurophysiology, psychiatry, and neurology. TMS allows neurostimulation and neuromodulation, while tDCS is a purely neuromodulatory application. TMS and tDCS allow diagnostic and interventional neurophysiology applications, and focal neuropharmacology delivery. However, the physics and basic mechanisms of action remain incompletely explored. Following an overview of the history and current applications of noninvasive brain stimulation, we review stimulation device design principles, the electromagnetic and physical foundations of the techniques, and the current knowledge about the electrophysiologic basis of the effects. Finally, we discuss potential biomedical and electrical engineering developments that could lead to more effective stimulation devices, better suited for the specific applications.

引用

页码：527 / 565

页数：39

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