Structural and topological differences between a glycopeptide-intermediate clinical strain and glycopeptide-susceptible strains of Staphylococcus aureus revealed by atomic force microscopy

被引：20

作者：

Boyle-Vavra, S

Hahm, J

Sibener, SJ

Daum, RS

机构：

[1] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

[2] Univ Chicago, James Franck Inst, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 12期

关键词：

D O I：

10.1128/AAC.44.12.3456-3460.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Novel cell surface topography was revealed on cocci from a glycopeptide-intermediate Staphylococcus aureus (GISA) clinical strain by using atomic force microscopy. The GISA isolate and its revertant had two parallel circumferential surface rings. One equatorial surface ring was observed in control strains. In vancomycin susceptible strains, additional rings were formed in the presence of vancomycin. Ring depth measurements also revealed striking differences between the GISA strain and susceptible strains grown with or without vancomycin.

引用

页码：3456 / 3460

页数：5

共 28 条

[1] Targeting of muralytic enzymes to the cell division site of Gram-positive bacteria:: repeat domains direct autolysin to the equatorial surface ring of Staphylococcus aureus [J].