Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells

被引：24

作者：

de Lima, Thais Martins ^{[1
]}

Amarante-Mendes, Gustavo P.

Curi, Rui ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508 Sao Paulo, Brazil

来源：

TOXICOLOGY IN VITRO | 2007年 / 21卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

imatinib; chronic myeloid leukemia; docosahexaenoic acid; HL-60; cells; Bcr-Abl;

D O I：

10.1016/j.tiv.2007.05.008

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 [卫生毒理学];

摘要：

The effect of docosahexaenoic acid (DHA) on the killing efficacy of imatinib on HL-60 cells expressing the Bcr-Abl protein was investigated. Imatinib is an AN tyrosine kinase inhibitor used in the treatment of patients with chronic myeloid leukemia. The pre-treatment with DHA for 24 It raised the effect of imatinib at 100 mu M concentration only. On the other hand, after 72 h pre-treatment, all concentrations of DHA tested (25, 50 and 100 mu M) enhanced the toxic effect of imatinib. These results indicate that long-term pre-treatment with DHA makes Bcr-Abl HL-60 cells more susceptible to the toxic effect of imatinib. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1678 / 1685

页数：8

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