Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0

被引：66

作者：

Beggs, Simon ^{[1
]}

Salter, Michael W. ^{[1
]}

机构：

[1] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M6H 2X6, Canada

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2010年 / 20卷 / 04期

基金：

加拿大健康研究院;

关键词：

PERIPHERAL-NERVE INJURY; RECEPTOR UP-REGULATION; LAMINA-I NEURONS; SPINAL-CORD; P2X(4) RECEPTORS; MECHANICAL ALLODYNIA; NEUROTROPHIC FACTOR; ANION GRADIENT; PROTEIN-KINASE; ACTIVATION;

D O I：

10.1016/j.conb.2010.08.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Microglia are increasingly recognized as critical in the pathogenesis of pain hypersensitivity caused by injury to peripheral nerves. The core signalling pathway is through P2X4 purinergic receptors on the microglia which, via the release of brain-derived neurotrophic factor, cause disinhibition of nociceptive dorsal horn neurons by raising intracellular chloride levels. This disinhibition works in synergy with enhanced excitatory synaptic transmission in the dorsal horn to transform the output of the nociceptive network. There is increased discharge output, unmasking of responses to innocuous peripheral inputs and spontaneous activity in neurons that otherwise only signal nociception. Together the changes caused by microglia-neuron signalling may account for the main symptoms of neuropathic pain in humans.

引用

页码：474 / 480

页数：7

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