Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression

被引:98
作者
Sagar, M
Lavreys, L
Baeten, JM
Richardson, BA
Mandaliya, K
Chohan, BH
Kreiss, JK
Overbaugh, J
机构
[1] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, Dept Publ Hlth Sci, Seattle, WA 98104 USA
[3] Univ Washington, Dept Med, Seattle, WA USA
[4] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[5] Univ Washington, Dept Biostat, Seattle, WA 98195 USA
[6] Coast Provincial Gen Hosp, Mombasa, Kenya
[7] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya
关键词
D O I
10.1128/JVI.77.23.12921-12926.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human immunodeficiency virus type 1 (HIV-1)-infected individuals develop a genetically diverse virus population over time, but often only a limited number of viral variants are transmitted from a chronic carrier to a newly infected person. Interestingly, many women but few men are infected by multiple HIV-1 variants from a single partner. To determine whether the complexity of the infecting virus population influences clinical outcome, we examined viral diversity in the HIV-1 envelope sequences present at primary infection in 156 women from Kenya for whom we had follow-up data on viral RNA levels and CD4 T-cell counts. Eighty-nine women had multiple viral genotypes, while 67 women had a single genotype at primary infection. Women who acquired multiple viral genotypes had a significantly higher viral load (median, 4.84 versus 4.64 log(10) copies/ml, P = 0.04) and a significantly lower CD4(+)-T-cell count (median, 416 versus 617 cells/mm(2), P = 0.01) 4 to 24 months after infection compared to women who were infected with a single viral genotype. These studies suggest that early HIV-1 genetic diversity is linked to faster disease progression.
引用
收藏
页码:12921 / 12926
页数:6
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