Physical determinants of cell organization in soft media

被引：113

作者：

Schwarz, US ^{[1
]}

Bischofs, IB

机构：

[1] Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany

[2] Heidelberg Univ, IWR, BIOMS, INF 368, D-69120 Heidelberg, Germany

来源：

MEDICAL ENGINEERING & PHYSICS | 2005年 / 27卷 / 09期

关键词：

cell-matrix adhesion; focal adhesions; cytoskeleton; mechanotransduction;

D O I：

10.1016/j.medengphy.2005.04.007

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Cell adhesion is an integral part of many physiological processes in tissues, including development, tissue maintenance, angiogenesis, and wound healing. Recent advances in materials science (including microcontact printing, soft lithography, microfluidics, and nanotechnology) have led to strongly improved control of extracellular ligand distribution and of the properties of the micromechanical environment. As a result, the investigation of cellular response to the physical properties of adhesive surfaces has become a very active area of research. Sophisticated use of elastic substrates has revealed that cell organization in soft media is determined by active mechanosensing at cell-matrix adhesions. In order to determine the underlying mechanisms, quantification and biophysical modelling are essential. In tissue engineering, theory might help to design new environments for cells. (c) 2005 IPEM. Published by Elsevier Ltd. All rights reserved.

引用

页码：763 / 772

页数：10

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