Medicine: K is for koagulation

被引：55

作者：

Sadler, JE ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

来源：

NATURE | 2004年 / 427卷 / 6974期

关键词：

D O I：

10.1038/427493a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Comparative genetic linkage studies in rats, mice and humans have finally identified a key component of vitamin K metabolism that is targeted by the commonest anticoagulant drugs in use today.

引用

页码：493 / 494

页数：2

共 5 条

[1] Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16 [J].

Fregin, A ;

Rost, S ;

Wolz, W ;

Krebsova, A ;

Muller, CR ;

Oldenburg, J .

BLOOD, 2002, 100 (09) :3229-3232

[2] A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans [J].

Kohn, MH ;

Pelz, HJ .

BLOOD, 2000, 96 (05) :1996-1998

[3] Identification of the gene for vitamin K epoxide reductase [J].

Li, T ;

Chang, CY ;

Jin, DY ;

Lin, PJ ;

Khvorova, A ;

Stafford, DW .

NATURE, 2004, 427 (6974) :541-544

[4] Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2 [J].

Rost, S ;

Fregin, A ;

Ivaskevicius, V ;

Conzelmann, E ;

Hörtnagel, K ;

Pelz, HJ ;

Lappegard, K ;

Seifried, E ;

Scharrer, I ;

Tuddenham, EGD ;

Müller, CR ;

Strom, TM ;

Oldenburg, J .

NATURE, 2004, 427 (6974) :537-541

[5] CLONING AND EXPRESSION OF THE CDNA FOR HUMAN GAMMA-GLUTAMYL CARBOXYLASE [J].

WU, SM ;

CHEUNG, WF ;

FRAZIER, D ;

STAFFORD, DW .

SCIENCE, 1991, 254 (5038) :1634-1636

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