Large-Scale Automated Histology in the Pursuit of Connectomes

被引：110

作者：

Kleinfeld, David ^{[1
,2
]}

Bharioke, Arjun ^{[3
]}

Blinder, Pablo ^{[1
]}

Bock, Davi D. ^{[3
]}

Briggman, Kevin L. ^{[5
]}

Chklovskii, Dmitri B. ^{[3
]}

Denk, Winfried ^{[3
,5
]}

Helmstaedter, Moritz ^{[5
]}

Kaufhold, John P. ^{[4
]}

Lee, Wei-Chung Allen ^{[6
]}

Meyer, Hanno S. ^{[7
]}

Micheva, Kristina D. ^{[8
]}

Oberlaender, Marcel ^{[7
]}

Prohaska, Steffen ^{[7
,9
]}

Reid, R. Clay ^{[6
]}

Smith, Stephen J. ^{[8
]}

Takemura, Shinya ^{[3
]}

Tsai, Philbert S. ^{[1
]}

Sakmann, Bert ^{[7
,10
]}

机构：

[1] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Neurobiol Sect, La Jolla, CA 92093 USA

[3] Howard Hughes Med Inst, Ashburn, VA USA

[4] SAIC Intelligent Syst Div, Arlington, VA 22102 USA

[5] Max Planck Inst Med Res, D-69120 Heidelberg, Germany

[6] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

[7] Max Planck Florida Inst, Jupiter, FL 33468 USA

[8] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA

[9] Zuse Inst Berlin, Dept Visualizat & Data Anal, D-14195 Berlin, Germany

[10] Max Planck Inst Neurobiol, D-82152 Martinsried, Germany

来源：

JOURNAL OF NEUROSCIENCE | 2011年 / 31卷 / 45期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

RAT VIBRISSAL CORTEX; ELEMENTARY MOVEMENT DETECTORS; STARBURST AMACRINE CELLS; PLASMA-MEDIATED ABLATION; HUMAN CEREBRAL-CORTEX; MOUSE VISUAL-CORTEX; IN-VIVO; RESPONSE PROPERTIES; INHIBITORY NEURONS; NERVOUS-SYSTEM;

D O I：

10.1523/JNEUROSCI.4077-11.2011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

How does the brain compute? Answering this question necessitates neuronal connectomes, annotated graphs of all synaptic connections within defined brain areas. Further, understanding the energetics of the brain's computations requires vascular graphs. The assembly of a connectome requires sensitive hardware tools to measure neuronal and neurovascular features in all three dimensions, as well as software and machine learning for data analysis and visualization. We present the state of the art on the reconstruction of circuits and vasculature that link brain anatomy and function. Analysis at the scale of tens of nanometers yields connections between identified neurons, while analysis at the micrometer scale yields probabilistic rules of connection between neurons and exact vascular connectivity.

引用

页码：16125 / 16138

页数：14

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