Conjugate pneumococcal vaccine in HIV-infected Ugandans and the effect of past receipt of polysaccharide vaccine

被引：37

作者：

Miiro, G

Kayhty, H

Watera, C

Tolmie, H

Whitworth, JAG

Gilks, CF

French, N

机构：

[1] Malawi Liverpool Wellcome Trust Labs, Blantyre, Malawi

[2] Med Res Council Programme AIDS, Entebbe, Uganda

[3] Natl Publ Hlth Inst, Helsinki, Finland

[4] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

[5] London Sch Hyg & Trop Med, London WC1, England

[6] Univ London Imperial Coll Sci Technol & Med, London, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1086/497144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the immunogenicity of a 7-valent conjugate pneumococcal vaccine (CPV) in human immunodeficiency virus - infected Ugandan adults and measured the effect of past pneumococcal polysaccharide vaccine (PPV) receipt given as part of a controlled trial. Two doses of CPV, 4 weeks apart, were given to 54 past PPV recipients and 55 past placebo recipients (84% female; median CD4 cell count, 251 cells/mu L [range, 1 - 936 cells/mu L]). Postvaccination anticapsular immunoglobulin G (IgG) concentrations were directly correlated with CD4 cell count (P < .01 for all serotypes). There were significant increases in anticapsular IgG concentrations for all serotypes after the first dose (P < .01) and for all serotypes except 14 and 9V after the second dose. Past receipt of PPV did not affect vaccine response.

引用

收藏

页码：1801 / 1805

页数：5

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