Radiation dose distributions in three dimensions from tomographic optical density scanning of polymer gels .1. Development of an optical scanner

被引:259
作者
Gore, JC
Ranade, M
Maryanski, MJ
Schulz, RJ
机构
[1] YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06510
[2] MGS RES INC,GUILFORD,CT 06437
[3] YALE UNIV,DEPT THERAPEUT RADIOL,NEW HAVEN,CT 06510
关键词
D O I
10.1088/0031-9155/41/12/009
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A new method of dosimetry of ionizing radiations has been developed that makes use of tissue-equivalent polymer gels which are capable of recording three-dimensional dose distributions. The dosimetric data stored within the gels are measured using optical tomographic densitometry. The dose-response mechanism relies on the production of light scattering microparticles which result from the polymerization of acrylic comonomers dispersed in the gel. The attenuation of a collimated Light beam caused by scattering in the irradiated optically turbid medium is directly related to the radiation dose over the range 0-10 Gy. An optical scanner has been developed which incorporates an He-Ne laser, photodiode detectors, and a rotating gel platform. Using mirrors mounted on a translating stage, the laser beam scans across the gel between each incremental rotation of the platform. Using the set of optical density projections obtained, a cross sectional image of the radiation field is then reconstructed. Doses in the range 0-10 Gy can be measured to better than 5% accuracy with a spatial resolution approximate to 2 mm using the current prototype scanner. This method can be used for the determination of three-dimensional dose distributions in irradiated gels, including measurements of the complex distributions produced by multi-leaf collimators, dynamic wedge and stereotactic treatments, and for quality assurance procedures.
引用
收藏
页码:2695 / 2704
页数:10
相关论文
共 7 条
[1]   STATISTICAL LIMITATIONS IN COMPUTED TOMOGRAPHY [J].
GORE, JC ;
TOFTS, PS .
PHYSICS IN MEDICINE AND BIOLOGY, 1978, 23 (06) :1176-1182
[2]   Radiation dose distributions in three dimensions from tomographic optical density scanning of polymer gels .2. Optical properties of the BANG polymer gel [J].
Maryanski, MJ ;
Zastavker, YZ ;
Gore, JC .
PHYSICS IN MEDICINE AND BIOLOGY, 1996, 41 (12) :2705-2717
[3]   MAGNETIC-RESONANCE-IMAGING OF RADIATION-DOSE DISTRIBUTIONS USING A POLYMER-GEL DOSIMETER [J].
MARYANSKI, MJ ;
SCHULZ, RJ ;
IBBOTT, GS ;
GATENBY, JC ;
XIE, J ;
HORTON, D ;
GORE, JC .
PHYSICS IN MEDICINE AND BIOLOGY, 1994, 39 (09) :1437-1455
[4]   Radiation therapy dosimetry using magnetic resonance imaging of polymer gels [J].
Maryanski, MJ ;
Ibbott, GS ;
Eastman, P ;
Schulz, RJ ;
Gore, JC .
MEDICAL PHYSICS, 1996, 23 (05) :699-705
[5]   3-DIMENSIONAL RECONSTRUCTION FROM RADIOGRAPHS AND ELECTRON MICROGRAPHS - APPLICATION OF CONVOLUTIONS INSTEAD OF FOURIER TRANSFORMS [J].
RAMACHANDRAN, GN ;
LAKSHMINARAYANAN, AV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (09) :2236-+
[6]   FOURIER RECONSTRUCTION OF A HEAD SECTION [J].
SHEPP, LA ;
LOGAN, BF .
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1974, NS21 (03) :21-43
[7]   SOME SOURCES OF ARTIFACT IN COMPUTED-TOMOGRAPHY [J].
TOFTS, PS ;
GORE, JC .
PHYSICS IN MEDICINE AND BIOLOGY, 1980, 25 (01) :117-127