Disturbed small intestinal motility in the late rat pregnancy

被引:13
作者
Chang, FY
Lee, SD
Yeh, GH
Lu, CC
Wang, PS
Wang, SW
机构
[1] Vet Gen Hosp, Div Gastroenterol, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Dept Physiol, Taipei 112, Taiwan
[3] Chang Gung Coll Med & Technol, Dept Physiol, Tao Yuan, Taiwan
关键词
gastric emptying; gastrointestinal transit; pregnancy; progesterone;
D O I
10.1159/000009971
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
We investigated whether various periods of pregnancy might disturb rat gastrointestinal motility. When the proestrus of female rats occurred, they were housed with male rats. Motility studies were conducted on day 7 (first period), day 14 (second) and day 21 (third) of pregnancy, respectively. After the orogastric feeding of radiochromium marker, rats were sacrificed 15 min later. Gastric emptyings of pregnant rats measured at various periods did not differ from the nonpregnant diestrus controls. The geometric center represented intestinal transits in the first, second and third periods of pregnancy and controls were (mean +/- SEM) 4.54 +/- 0.25, 4.47 +/- 0.17, 3.61 +/- 0.27 and 4.98 +/- 0.13, respectively (p < 0.01) while their plasma progesterone levels were 15.6 +/- 2.6, 18 +/- 1.4, 7.1 +/- 0.5 and 8.6 +/- 0.4 ng/ml, respectively (p < 0.01). This shows that late pregnancy inhibits small intestinal transit, whereas gastric emptying remains unchanged. Altered progesterone during pregnancy is not a main mediator to disturb intestinal transit.
引用
收藏
页码:221 / 224
页数:4
相关论文
共 25 条
  • [1] POSTPARTUM RESTORATION OF PREGNANCY-INDUCED CHOLECYSTOPARESIS AND PROLONGED INTESTINAL TRANSIT-TIME
    BRAVERMAN, DZ
    HERBET, D
    GOLDSTEIN, R
    PERSITZ, E
    EYLATH, U
    JACOBSOHN, WZ
    [J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 1988, 10 (06) : 642 - 646
  • [2] PROGESTERONE EFFECTS ON 3 REGIONAL GASTRO-INTESTINAL TISSUES
    BRUCE, LA
    BEHSUDI, FM
    [J]. LIFE SCIENCES, 1979, 25 (09) : 729 - 734
  • [3] COMPARISON OF 2 OROGASTRIC FEEDING MARKERS FOR MEASURING GASTROINTESTINAL MOTOR FUNCTIONS IN RATS
    CHANG, FY
    LEE, SD
    YEH, GH
    WANG, PS
    [J]. PHARMACOLOGY, 1994, 49 (03) : 151 - 158
  • [4] EFFECTS OF SEX STEROID-HORMONES ON GASTRIC-EMPTYING AND GASTROINTESTINAL TRANSIT IN RATS
    CHEN, TS
    DOONG, ML
    CHANG, FY
    LEE, SD
    WANG, PS
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1995, 268 (01): : G171 - G176
  • [5] GASTRIC-EMPTYING FOLLOWING PREMEDICATION WITH GLYCOPYRROLATE OR ATROPINE
    CLARK, JM
    SEAGER, SJ
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 1983, 55 (12) : 1195 - 1199
  • [6] HYPOTHALAMIC OPIATERGIC TONE DURING PREGNANCY, PARTURITION AND LACTATION IN THE RAT
    DONDI, D
    MAGGI, R
    PANERAI, AE
    PIVA, F
    LIMONTA, P
    [J]. NEUROENDOCRINOLOGY, 1991, 53 (05) : 460 - 466
  • [7] EVERSON GT, 1992, GASTROENTEROL CLIN N, V21, P751
  • [8] HORMONE PROFILES FOR PROGESTERONE, ESTRADIOL, PROLACTIN, PLASMA-RENIN ACTIVITY, ALDOSTERONE AND CORTICOSTERONE DURING PREGNANCY AND PSEUDOPREGNANCY IN 2 STRAINS OF RAT - CORRELATION WITH RENAL STUDIES
    GARLAND, HO
    ATHERTON, JC
    BAYLIS, C
    MORGAN, MRA
    MILNE, CM
    [J]. JOURNAL OF ENDOCRINOLOGY, 1987, 113 (03) : 435 - 444
  • [9] HEY VM, 1975, GUT, V16, P403
  • [10] HOMNES PJ, 1979, J CLIN ENDOCR METAB, V48, P506