Combinatorial enzymatic synthesis of heparan sulfate

被引：13

作者：

Linhardt, Robert J. ^{[1
]}

Kim, Jin-Hwan ^{[1
]}

机构：

[1] Ctr Biotechnol & Interdisciplinary Studies, Rensselaer Polytech Inst, Dept Chem & Biol Chem, Troy, NY 12180 USA

来源：

CHEMISTRY & BIOLOGY | 2007年 / 14卷 / 09期

关键词：

D O I：

10.1016/j.chembiol.2007.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Escherichia coli K5 heparosan was enzymatically modified by Chen and colleagues [10] to construct a library of heparan sulfate polysaccharides for evaluation, leading to the discovery that a 2-O-sulfo-iduronic acid residue is not essential for antithrombin-mediated anticoagulant activity in larger oligosaccharide and polysaccharide structures.

引用

收藏

页码：972 / 973

页数：2

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