Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

被引：557

作者：

Sauvageau, Martin ^{[1
]}

Sauvageau, Guy ^{[1
,2
]}

机构：

[1] Univ Montreal, Mol Genet Stem Cells Lab, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada

[2] Maisonneuve Rosemont Hosp, Div Hematol & Leukemia Cell Bank Quebec, Montreal, PQ H1T 2M4, Canada

来源：

CELL STEM CELL | 2010年 / 7卷 / 03期

基金：

加拿大健康研究院;

关键词：

RNA-POLYMERASE-II; HISTONE METHYLTRANSFERASE ACTIVITY; TUMOR-SUPPRESSIVE MICRORNAS; BREAST EPITHELIAL-CELLS; ACUTE MYELOID-LEUKEMIA; DNA-DAMAGE RESPONSE; H3; LYSINE; 27; HEMATOPOIETIC STEM; SELF-RENEWAL; GENE-EXPRESSION;

D O I：

10.1016/j.stem.2010.08.002

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify chromatin and participate in the establishment and maintenance of cell fates. These proteins play important roles in both stem cell self-renewal and in cancer development. Our understanding of their mechanism of action has greatly advanced over the past 10 years, but many unanswered questions remain. In this review, we present the currently available experimental data that connect PcG protein function with some of the key processes which govern somatic stem cell activity. We also highlight recent studies suggesting that a delicate balance in PcG gene dosage is crucial for proper stem cell homeostasis and prevention of cancer stem cell development.

引用

页码：299 / 313

页数：15

共 189 条

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