Cerebral Whipple's disease: clinical and cerebrospinal fluid findings

被引:5
作者
Carella, F [1 ]
Valla, P
Bernardi, G
Parente, F
Costa, A
Lodrini, S
机构
[1] Natl Neurol Inst C Besta, Dept Neurol, I-20133 Milan, Italy
[2] Natl Neurol Inst C Besta, Gen Lab, Milan, Italy
[3] Hosp L Sacco, Dept Gastroenterol, Milan, Italy
[4] Natl Neurol Inst C Besta, Dept Neuroradiol, Milan, Italy
[5] Natl Neurol Inst C Besta, Dept Neurosurg, Milan, Italy
来源
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1998年 / 19卷 / 02期
关键词
Whipple's disease; cerebrospinal fluid; immunoglobulins;
D O I
10.1007/BF02427566
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The case of a patient who had a relapse of cerebral Whipple 's disease (WD) one year after discontinuation of a two-years' antibiotic treatment is reported. Neither the clinical course nor the results of magnetic resonance imaging (MRI) and routine examination of the cerebrospinal fluid (CSF) allowed the caring physician to predict the relapse. Retrospective analysis of serial specimens of CSF showed that slight CSF leucocytosis and intrathecal synthesis of IgA might have suggested persistence of infection. The decision to stop antibiotic therapy in cerebral WD is difficult, but evaluation of cell counts and of intrathecal synthesis of IgA may help in the decision. Some patients may need to take treatment indefinitely.
引用
收藏
页码:101 / 105
页数:5
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