Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS)

被引：11

作者：

Curtis, MA ^{[1
]}

Varkhedkar, V ^{[1
]}

Pragnacharyulu, PVP ^{[1
]}

Abushanab, E ^{[1
]}

机构：

[1] Univ Rhode Isl, Dept Biomed Sci, Kingston, RI 02881 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(98)00291-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 9-aralkyladenines have been prepared and their ADA inhibitory activity was determined. A minimum of two carbon atoms separating the aromatic ring from the adenine-bearing carbon (C3') was found essential for potent activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1639 / 1642

页数：4

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