Loss of Muscle Strength, Mass (Sarcopenia), and Quality (Specific Force) and Its Relationship with Functional Limitation and Physical Disability: The Concord Health and Ageing in Men Project

被引：373

作者：

Hairi, Noran N. ^{[1
,2
,6
]}

Cumming, Robert G. ^{[2
,3
,4
]}

Naganathan, Vasi ^{[3
]}

Handelsman, David J. ^{[4
]}

Le Couteur, David G. ^{[3
,4
]}

Creasey, Helen ^{[3
]}

Waite, Louise M. ^{[3
]}

Seibel, Markus J. ^{[4
]}

Sambrook, Philip N. ^{[5
]}

机构：

[1] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur 50603, Malaysia

[2] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

[3] Univ Sydney, Ctr Educ & Res Ageing, Sydney, NSW 2006, Australia

[4] Univ Sydney, ANZAC Res Inst, Concord Repatriat Gen Hosp, Sydney, NSW 2006, Australia

[5] Univ Sydney, Inst Bone & Joint Res, Royal N Shore Hosp, Sydney, NSW 2006, Australia

[6] Univ Malaya, Fac Med, Ctr Clin Epidemiol & Evidence Based Med, Julius Ctr, Kuala Lumpur 50603, Malaysia

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2010年 / 58卷 / 11期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

muscle strength; muscle mass; muscle quality; functional limitation; physical disability; LOWER-EXTREMITY PERFORMANCE; SKELETAL-MUSCLE; ALTERNATIVE DEFINITIONS; HANDGRIP STRENGTH; OLDER PERSONS; SELF-REPORT; AGED; 75; IMPAIRMENT; ADULTS; WOMEN;

D O I：

10.1111/j.1532-5415.2010.03145.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

OBJECTIVES: To determine the association between loss of muscle strength, mass, and quality and functional limitation and physical disability in older men. DESIGN: Cross-sectional study of older men participating in the Concord Health and Ageing in Men Project (CHAMP). SETTING: Elderly men living in a defined geographical region in Sydney, Australia. PARTICIPANTS: One thousand seven hundred five community-dwelling men aged 70 and older who participated in the baseline assessments of CHAMP. MEASUREMENTS: Upper and lower extremity strength were measured using dynamometers for grip and quadriceps strength. Appendicular skeletal lean mass was assessed using dual X-ray absorptiometry. Muscle quality was defined as the ratio of strength to mass in upper and lower extremities. For each parameter, subjects in the lowest 20% of the distribution were defined as below normal. Functional limitation was assessed according to self-report and objective lower extremity performance measures. Physical disability was measured according to self-report questionnaire. RESULTS: After adjusting for important confounders, the prevalence ratio (PR) for poor quadriceps strength and self-reported functional limitation was 1.91 (95% confidence interval (CI) 51.10-2.40); for performance-based functional limitation the PR was 1.81 (95% CI = 1.45-2.24). The adjusted PR for poor grip strength and physical disability in instrumental activities of daily living (IADLs) was 1.37 (95% CI = 1.20-1.56). The adjusted PR for low skeletal lean mass (adjusted for fat mass) and physical disability in basic activities of daily living was 2.08 (95% CI = 1.37-3.15). For muscle quality, the PR for lower extremity specific force and functional limitation and physical disability was stronger than upper extremity specific force. CONCLUSION: Muscle strength is the single best measure of age-related muscle change and is associated with physical disability in IADLs and functional limitation. J Am Geriatr Soc 58:2055-2062, 2010.

引用

页码：2055 / 2062

页数：8

共 47 条

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