Proline-catalyzed asymmetric aldol reactions between ketones and α-unsubstituted aldehydes

被引：405

作者：

List, B

Pojarliev, P

Castello, C

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 04期

关键词：

D O I：

10.1021/ol006976y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] With this communication we extend the methodology of proline-catalyzed direct asymmetric aldol reactions to include a unsubstituted aldehydes as accepters. This important aldehyde class gives the corresponding aldols in 22-77% yield and up to 95% ee when the reactions are performed in pure acetone or in ketone/chloroform mixtures. On the basis of these results we have developed a concise new synthesis of (S)-ipsenol.

引用

页码：573 / 575

页数：3

共 25 条

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