Expression systems and physiological control of promoter activity in bacteria

被引：44

作者：

Cases, I ^{[1
]}

de Lorenzo, V ^{[1
]}

机构：

[1] CSIC, Ctr Nacl Biotecnol, Madrid 28049, Spain

来源：

CURRENT OPINION IN MICROBIOLOGY | 1998年 / 1卷 / 03期

关键词：

D O I：

10.1016/S1369-5274(98)80034-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Promoter activity in vivo is not just dependent on the performance of the regulator/promoter pair which may predominantly control transcription initiation in response to a given signal, it also relies on overimposed mechanisms that connect the activity of individual promoters to the metabolic and energetic status of the bacterial cells. Such mechanisms - which frequently become limiting for biotechnological applications involving regulated promoters - include classic (i.e, cAMP/CRP-mediated) or alternative catabolite control checks, recruitment of protein intermediates of the phosphotransferase sugar transport system, coregulation through protein-induced DNA bending and the interplay of sigma factors during various growth stages.

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收藏

页码：303 / 310

页数：8

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