The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and acute leukemias

被引：55

作者：

Shankar, DB

Sakamoto, KM

机构：

[1] Univ Calif Los Angeles, Mattel Childrens Hosp, David Geffen Sch Med, Div Hematol Oncol,Gwynne Hazen Cherry Mem Labs, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, David Geffen Sch Med, Mol Biol Inst,Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[3] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

LEUKEMIA & LYMPHOMA | 2004年 / 45卷 / 02期

关键词：

leukemia; CREB; transcription factors; hematopoiesis; signal transduction;

D O I：

10.1080/1042819031000151095

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Leukemia is a result of accumulating genetic alterations. The collaboration of mutations that offer survival and proliferative signals, together with mutations that result in lack of differentiation, is thought to cause a leukemic phenotype. The cyclic-AMP Response Element Binding Protein (CREB) is a transcription factor that is known to be a downstream component of the GM-CSF and IL-3 signaling pathways. We previously showed that CREB is overexpressed in blast cells from patients with acute leukemias. In this paper, we review the role of CREB in hematopoiesis, cell proliferation and acute leukemias.

引用

页码：265 / 270

页数：6

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