CuI-fesulphos complexes:: efficient chiral catalysts for asymmetric 1,3-dipolar cycloaddition of azomethine ylides

被引：108

作者：

Cabrera, Silvia ^{[1
]}

Arrayas, Ramon Gomez ^{[1
]}

Martin-Matute, Belen ^{[1
]}

Cossio, Fernando P. ^{[2
]}

Carretero, Juan C. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, Madrid 28049, Spain

[2] Euskal Herriko Unibertsitatea, Kimika Fac, San Sebastian, Spain

来源：

TETRAHEDRON | 2007年 / 63卷 / 28期

关键词：

D O I：

10.1016/j.tet.2007.03.130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Cu-I-Fesulphos catalyst system (<= 3 mol %) shows an excellent performance in the asymmetric 1,3-dipolar cycloaddition of azomethine ylides. High to very high levels of reactivity, endo/exo selectivity, and enantioselectivity ( 69->99% ee) are generally achieved with a very wide range of azomethine ylides and dipolarophiles. Based on experimental and computational studies data, a model that accounts for this high enantiocontrol is proposed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6587 / 6602

页数：16

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