Characterization of ST-4821 complex, a unique Neisseria meningitidis clone

被引：59

作者：

Peng, Junping ^{[1
]}

Yang, Li ^{[1
,2
]}

Yang, Fan ^{[1
]}

Yang, Jian ^{[1
]}

Yan, Yongliang ^{[1
]}

Nie, Huan ^{[1
]}

Zhang, Xiaobing ^{[1
]}

Xiong, Zhaohui ^{[1
]}

Jiang, Yan ^{[1
]}

Cheng, Fan ^{[1
]}

Xu, Xingye ^{[1
]}

Chen, Shuxia ^{[1
]}

Sun, Lilian ^{[1
]}

Li, Weijun ^{[1
]}

Shen, Yan ^{[3
]}

Shao, Zhujun ^{[4
,5
]}

Liang, Xiaofeng ^{[6
]}

Xu, Jianguo ^{[4
,5
]}

Jin, Qi ^{[1
]}

机构：

[1] Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, Beijing 100052, Peoples R China

[2] Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China

[3] Natl Ctr Human Genome Res, Beijing 100176, Peoples R China

[4] Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China

[5] State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China

[6] Natl Immunizat Program Ctr, Beijing 102206, Peoples R China

来源：

GENOMICS | 2008年 / 91卷 / 01期

关键词：

Neisseria meningitidis; comparative genomics; infectious disease; ST-4821; complex;

D O I：

10.1016/j.ygeno.2007.10.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ten outbreaks of a new serogroup, C meningococcal disease emerged during 2003-2005 in China. The multilocus sequence typing results indicated that unique sequence type 4821 clone meningococci were responsible for these outbreaks. Herein, we determined the entire genomic DNA sequence of serogroup, C isolate 053442, which belongs to ST-4821. Comparison of 053442 gene contents with other meningococcal genomes shows that they have similar characteristics, including thousands of repetitive elements and simple sequence repeats, numerous phase-variable genes, and similar virulence-related factors. However, many strain-specific regions were found in each genome. We also present the results of a genomic comparison of 28 ST-4821 complex isolates that were isolated from different serogroups using comparative genomic hybridization analysis. Genome comparison between the newly emerged hyperinvasive isolates belonging to different serogroups will further our understanding of their respective pathogenetic mechanisms. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：78 / 87

页数：10

共 49 条

[1] Competence for natural transformation in Neisseria gonorrhoeae:: components of DNA binding and uptake linked to type IV pilus expression [J].

Aas, FE ;

Wolfgang, M ;

Frye, S ;

Dunham, S ;

Lovold, C ;

Koomey, M .

MOLECULAR MICROBIOLOGY, 2002, 46 (03) :749-760

[2] Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18 [J].

Bentley, Stephen D. ;

Vernikos, George S. ;

Snyder, Lori A. S. ;

Churcher, Carol ;

Arrowsmith, Claire ;

Chillingworth, Tracey ;

Cronin, Ann ;

Davis, Paul H. ;

Holroyd, Nancy E. ;

Jagels, Kay ;

Maddison, Mark ;

Moule, Sharon ;

Rabbinowitsch, Ester ;

Sharp, Sarah ;

Unwin, Louise ;

Whitehead, Sally ;

Quail, Michael A. ;

Achtman, Mark ;

Barrell, Bart ;

Saunders, Nigel J. ;

Parkhill, Julian .

PLOS GENETICS, 2007, 3 (02) :230-240

[3] A chromosomally integrated bacteriophage in invasive meningococci [J].

Bille, E ;

Zahar, JR ;

Perrin, A ;

Morelle, S ;

Kriz, P ;

Jolley, KA ;

Maiden, MCJ ;

Dervin, C ;

Nassif, X ;

Tinsley, CR .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (12) :1905-1913

[4] Characterization of mononucleotide repeats in sequenced prokaryotic genomes [J].

Coenye, Tom ;

Vandamme, Peter .

DNA RESEARCH, 2005, 12 (04) :221-233

[5] NadA diversity and carriage in Neisseria meningitidis [J].

Comanducci, M ;

Bambini, S ;

Caugant, DA ;

Mora, M ;

Brunelli, B ;

Capecchi, B ;

Ciucchi, L ;

Rappuoli, R ;

Pizza, M .

INFECTION AND IMMUNITY, 2004, 72 (07) :4217-4223

[6] NadA, a novel vaccine candidate of Neisseria meningitidis [J].

Comanducci, M ;

Bambini, S ;

Brunelli, B ;

Adu-Bobie, J ;

Aricò, B ;

Capecchi, B ;

Giuliani, MM ;

Masignani, V ;

Santini, L ;

Savino, S ;

Granoff, DM ;

Caugant, DA ;

Pizza, M ;

Rappuoli, R ;

Mora, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (11) :1445-1454

[7] Meningococcal genome dynamics [J].

Davidsen, T ;

Tonjum, T .

NATURE REVIEWS MICROBIOLOGY, 2006, 4 (01) :11-22

[8]

Ewing J, 1908, ARCH INTERN MED, V1, P175

[9] IDENTIFICATION AND ARRANGEMENT OF THE DNA-SEQUENCE RECOGNIZED IN SPECIFIC TRANSFORMATION OF NEISSERIA-GONORRHOEAE [J].

GOODMAN, SD ;

SCOCCA, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6982-6986

[10] Consed: A graphical tool for sequence finishing [J].

Gordon, D ;

Abajian, C ;

Green, P .

GENOME RESEARCH, 1998, 8 (03) :195-202

← 1 2 3 4 5 →