Clinical Immunology and Immunopathology of the Canine and Feline Intestine

被引：44

作者：

Allenspach, Karin ^{[1
]}

机构：

[1] Univ London, Royal Vet Coll, N Mymms AL9 7PT, England

来源：

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE | 2011年 / 41卷 / 02期

关键词：

Gut-associated lymphoid tissue; IgA; Innate immunity; Toll-like receptors; Microbiome; Inflammatory bowel disease; INFLAMMATORY-BOWEL-DISEASE; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; INVASIVE ESCHERICHIA-COLI; GERMAN-SHEPHERD DOGS; POLYMERASE-CHAIN-REACTION; REGULATES MICROBIAL COMMUNITIES; INDUCED CYTIDINE DEAMINASE; PROPRIA DENDRITIC CELLS; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTORS;

D O I：

10.1016/j.cvsm.2011.01.004

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

The mucosal immune system is at the forefront of defense against invading pathogens, but at the same time, it must maintain tolerance toward commensals and food antigens in the intestinal lumen. The interplay between the innate immune response and commensal microorganisms is essential to maintaining this balance. Great progress has been made in identifying some of the genetic predispositions underlying inflammatory bowel disease in certain breeds, such as the German shepherd dog. Several immunologic markers are discussed with respect to their clinical usefulness in the diagnosis and management of inflammatory bowel disease.

引用

页码：345 / +

页数：17

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