Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice

被引:192
作者
Fenech, Michael [1 ]
El-Sohemy, Ahmed [2 ]
Cahill, Leah [2 ]
Ferguson, Lynnette R. [3 ,8 ]
French, Tapaeru-Ariki C. [3 ,8 ]
Tai, E. Shyong [5 ]
Milner, John [4 ]
Koh, Woon-Puay [6 ]
Xie, Lin [7 ]
Zucker, Michelle [1 ]
Buckley, Michael [1 ]
Cosgrove, Leah [1 ]
Lockett, Trevor [1 ]
Fung, Kim Y. C. [1 ]
Head, Richard [1 ]
机构
[1] CSIRO Preventat Hlth Natl Res Flagship, Adelaide, SA 5000, Australia
[2] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada
[3] Univ Auckland, Discipline Nutr, Fac Med & Hlth Sci, Auckland 1, New Zealand
[4] NCI, Nutr Sci Res Grp, Canc Prevent Div, NIH, Rockville, MD USA
[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore
[6] Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117595, Singapore
[7] Jilin Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Changchun 130023, Peoples R China
[8] Nutrigen New Zealand, Auckland, New Zealand
关键词
Dietetics; Nutrigenetics; Nutrigenomics; Nutrition Research; Personalised nutrition; BODY-MASS INDEX; GENOME-HEALTH NUTRIGENOMICS; PROTEIN-COUPLED RECEPTOR; CORONARY-HEART-DISEASE; ADVERSE DRUG-REACTIONS; CHAIN FATTY-ACIDS; COLORECTAL-CANCER; GENE-EXPRESSION; FTO GENE; INSULIN-RESISTANCE;
D O I
10.1159/000327772
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学];
摘要
Nutrigenetics and nutrigenomics hold much promise for providing better nutritional advice to the public generally, genetic subgroups and individuals. Because nutrigenetics and nutrigenomics require a deep understanding of nutrition, genetics and biochemistry and ever new 'omic' technologies, it is often difficult, even for educated professionals, to appreciate their relevance to the practice of preventive approaches for optimising health, delaying onset of disease and diminishing its severity. This review discusses (i) the basic concepts, technical terms and technology involved in nutrigenetics and nutrigenomics; (ii) how this emerging knowledge can be applied to optimise health, prevent and treat diseases; (iii) how to read, understand and interpret nutrigenetic and nutrigenomic research results, and (iv) how this knowledge may potentially transform nutrition and dietetic practice, and the implications of such a transformation. This is in effect an up-to-date overview of the various aspects of nutrigenetics and nutrigenomics relevant to health practitioners who are seeking a better understanding of this new frontier in nutrition research and its potential application to dietetic practice. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:69 / 89
页数:21
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