S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

被引：516

作者：

Huang, Yuefeng ^{[1
]}

Mao, Kairui ^{[2
]}

Chen, Xi ^{[1
]}

Sun, Ming-an ^{[3
]}

Kawabe, Takeshi ^{[1
]}

Li, Weizhe ^{[2
]}

Usher, Nicholas ^{[1
,4
]}

Zhu, Jinfang ^{[1
]}

Urban, Joseph F., Jr. ^{[5
]}

Paul, William E. ^{[1
]}

Germain, Ronald N. ^{[1
,2
]}

机构：

[1] NIAID, Lab Immunol, NIH, Bethesda, MD 20892 USA

[2] NIAID, Lab Syst Biol, NIH, Bethesda, MD 20892 USA

[3] Eunice Kennedy Shriver Natl Inst Child Hlth & Hu, NIH, Bethesda, MD 20892 USA

[4] Cornell Univ, Dept Undergrad Biol, Ithaca, NY 14853 USA

[5] ARS, Diet Gen & Immunol Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA

来源：

SCIENCE | 2018年 / 359卷 / 6371期

关键词：

T-CELLS; TYPE-2; IMMUNITY; TUFT CELLS; INFLAMMATION; RECEPTOR; EGRESS; S1P(1);

D O I：

10.1126/science.aam5809

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have been considered to be tissue-resident cells, but whether ILCs move between tissue sites during infection has been unclear. We show here that interleukin-25- or helminth-induced inflammatory ILC2s are circulating cells that arise from resting ILC2s residing in intestinal lamina propria. They migrate to diverse tissues based on sphingosine 1-phosphate (S1P)-mediated chemotaxis that promotes lymphatic entry, blood circulation, and accumulation in peripheral sites, including the lung, where they contribute to anti-helminth defense and tissue repair. This ILC2 expansion and migration is a behavioral parallel to the antigen-driven proliferation and migration of adaptive lymphocytes to effector sites and indicates that ILCs complement adaptive immunity by providing both local and distant tissue protection during infection.

引用

页码：114 / 119

页数：6

共 33 条

[1]

Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration [J].