Inappropriate sinus tachycardia: focus on ivabradine

被引：21

作者：

Abed, H. S. ^{[1
,2
]}

Fulcher, J. R. ^{[1
,2
]}

Kilborn, M. J. ^{[1
,2
]}

Keech, A. C. ^{[1
,2
]}

机构：

[1] Univ Sydney, Dept Cardiol, Royal Prince Alfred Hosp, K25 Med Fdn Bldg, Sydney, NSW 2006, Australia

[2] Univ Sydney, NHMRC Clin Trials Ctr, K25 Med Fdn Bldg, Sydney, NSW 2006, Australia

来源：

INTERNAL MEDICINE JOURNAL | 2016年 / 46卷 / 08期

关键词：

inappropriate sinus tachycardia; ivabradine; JUNCTIONAL RECIPROCATING TACHYCARDIA; RADIOFREQUENCY CATHETER ABLATION; F INHIBITOR IVABRADINE; DOUBLE-BLIND; HEART-RATE; EFFICACY; ARRHYTHMIAS; RATIONALE; MECHANISM; CROSSOVER;

D O I：

10.1111/imj.13093

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Inappropriate sinus tachycardia (IST) is an incompletely understood condition, characterised by an elevation in heart rate (HR) accompanied by wide ranging symptoms in the absence of an underlying physiological stimulus. The condition often takes a chronic course with significant adverse effects on quality of life. Currently, there is no effective treatment for IST. Beta-blockers, generally considered the cornerstone of treatment, are often ineffective and poorly tolerated. Ivabradine is a novel sinus node I-f funny current' inhibitor, which reduces the HR. It has been approved for the treatment of beta-blocker refractory chronic systolic heart failure and chronic stable angina but more recently has shown promise in the treatment of IST. This review provides an overview of IST prevalence and mechanisms followed by an examination of the evidence for the role and efficacy of ivabradine in the treatment of IST.

引用

页码：875 / 883

页数：9

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