Indoloquinazoline alkaloids from Euodia rutaecarpa and their cytotoxic activities

被引：44

作者：

Huang, Xin ^{[1
]}

Zhang, You-Bo ^{[1
]}

Yang, Xiu-Wei ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2011年 / 13卷 / 11期

关键词：

Euodia rutaecarpa; indoloquinazoline alkaloids; (7R; 8S)-7-hydroxy-8-methoxy-rutaecarpine; 8S)-7-hydroxy-8-ethoxy-rutaecarpine; human promyelocytic leukemia HL-60 cell; human gastric carcinoma N-87 cells; EVODIA-RUTAECARPA; FRUITS; FRUCTUS;

D O I：

10.1080/10286020.2011.602015

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Nine indoloquinazoline alkaloids (1-9) were isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. (Euodiae Fructus), along with limonin and beta-sitosterol. Their structures were elucidated on the basis of their spectroscopic data. Among them, compounds 1 and 2 were new compounds and characterized as (7R,8S)-7-hydroxy-8-methoxy-rutaecarpine and (7R,8S)-7-hydroxy-8-ethoxy-rutaecarpine, respectively, and 1-hydroxy-rutaecarpine (3) and (7R,8S)-7,8-dihydroxy-rutaecarpine (4) were isolated from Euodiae Fructus for the first time. The nine indoloquinazoline alkaloids were evaluated for their cytotoxic activities against human promyelocytic leukemia HL-60 cells and human gastric carcinoma N-87 cells.

引用

页码：977 / 983

页数：7

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