Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat

被引：35

作者：

Shumake, J

Edwards, E

Gonzalez-Lima, F ^{[1
]}

机构：

[1] Univ Texas, Dept Psychol, Austin, TX 78712 USA

[2] Univ Texas, Inst Neurosci, Austin, TX 78712 USA

[3] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

来源：

NEUROSCIENCE LETTERS | 2001年 / 311卷 / 01期

关键词：

paraventricular hypothalamic nucleus; congenital helplessness; cytochrome oxidase; depression; hypothalamus; metabolism; animal model; rat;

D O I：

10.1016/S0304-3940(01)02142-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The congenitally helpless rat, selectively bred to model behavioral features of depression, has shown metabolic activity patterns in frontal and cingulate cortex similar to those detected in human imaging studies of depression and sadness. This study extends the same metabolic mapping technique (quantitative cytochrome oxidase histochemistry) to the hypothalamus, where activity levels were assessed in six nuclei: paraventricular nucleus, medial preoptic area, lateral hypothalamic area, supraoptic nucleus, suprachiasmatic nucleus, and ventromedial nucleus. Helpless rats were compared with a strain of non-helpless rats selectively bred for stress resistance. Only the paraventricular nucleus showed a significant group difference, with helpless rats showing elevated metabolism and non-helpless rats showing reduced metabolism relative to normal rats. Thus, paraventricular nucleus activity may be associated with genetic susceptibility to helpless behavior. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：45 / 48

页数：4

共 20 条

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