Salivary glands: novel target sites for gene therapeutics

被引：49

作者：

Baum, BJ ^{[1
]}

Voutetakis, A ^{[1
]}

Wang, JH ^{[1
]}

机构：

[1] Natl Inst Dental & Craniofacial Res, Gene Therapy & Therapeut Branch, NIH, DHHS, Bethesda, MD 20892 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 12期

关键词：

D O I：

10.1016/j.molmed.2004.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Directing the local or systemic expression of therapeutic proteins is a potentially important clinical application of gene transfer technology. Gene-based therapeutics theoretically offer many advantages over protein therapeutics. Numerous tissues have been evaluated for this purpose in animal models, most commonly the liver and skeletal muscle. Based on pre-clinical studies, we suggest that salivary glands are a valuable, yet underappreciated, target tissue for both systemic and upper gastrointestinal tract gene therapeutic applications.

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页码：585 / 590

页数：6

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