Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1

被引：41

作者：

Ko, SR

Suzuki, Y

Choi, KJ

Kim, YH

机构：

[1] Okayama Univ, Bioresources Res Inst, Kurashiki, Okayama 7100046, Japan

[2] Korea Ginseng & Tobacco Res Inst, Yusong Ku, Taejon 305345, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2000年 / 64卷 / 12期

关键词：

ginsenoside Re; ginsenoside Rg(1); ginsenoside Rh-1; ginsenoside Rg(2); Penicillium sp lactase;

D O I：

10.1271/bbb.64.2739

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

It was found that a lactase preparation from Penicillium sp. nearly quantitatively hydrolyzed ginsenosides Re and Rg(1), which are major saponins in roots of Panax ginseng, to a minor saponin, 20(S)-ginsenoside Rh-1 [6-O-beta -D-glucopyranosyl-20(S)-protopanaxatriol]. This is the first report on the enzymatic preparation of ginsenoside Rh-1 with a high efficiency. This enzyme also readily hydrolyzed ginsenoside Rg(2) to ginsenoside Rh-1.

引用

页码：2739 / 2743

页数：5

共 17 条

[1]

BAEK NI, 1993, P 6 INT GINS S SEOUL, P132

[2]

CHEN Y, 1987, CHEM PHARM BULL, V35, P1653

[3]

Elyakov GB, 1993, P 6 INT GINS S SEOUL, P74

[4]

DEGRADATION OF GINSENG SAPONINS UNDER MILD ACIDIC CONDITIONS [J].

HAN, BH ;

PARK, MH ;

HAN, YN ;

WOO, LK ;

SANKAWA, U ;

YAHARA, S ;

TANAKA, O .

PLANTA MEDICA, 1982, 44 (03) :146-149

[5]

ENZYMATIC-HYDROLYSIS OF GINSENG SAPONINS AND THEIR RELATED GLYCOSIDES [J].

KOHDA, H ;

TANAKA, O .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1975, 95 (02) :246-249

[6]

KOIZUMI H, 1982, CHEM PHARM BULL, V30, P2393

[7]

LEE HY, 1993, P 6 INT GINS S SEOUL, P127

[8]

ODASHIMA S, 1985, CANCER RES, V45, P2781

[9]

OTA T, 1987, CANCER RES, V47, P3863

[10]

Park M. T., 1998, J GINSENG RES, V22, P216

← 1 2 →