Multifunction Sr, Co and F co-doped microporous coating on titanium of antibacterial, angiogenic and osteogenic activities

被引：77

作者：

Zhou, Jianhong ^{[1
]}

Zhao, Lingzhou ^{[2
]}

机构：

[1] Baoji Univ Arts & Sci, Inst Phys & Optoelect Technol, Baoji 721016, Peoples R China

[2] Fourth Mil Med Univ, Sch Stomatol, Dept Periodontol, State Key Lab Mil Stomatol, Xian 710032, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国博士后科学基金; 中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

CALCIUM-PHOSPHATE COATINGS; MESENCHYMAL STEM-CELLS; IN-VITRO BIOACTIVITY; TIO2; COATINGS; BONE; HYDROXYAPATITE; STRONTIUM; SCAFFOLDS; COBALT; OXIDATION;

D O I：

10.1038/srep29069

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Advanced multifunction titanium (Ti) based bone implant with antibacterial, angiogenic and osteogenic activities is stringently needed in clinic, which may be accomplished via incorporation of proper inorganic bioactive elements. In this work, microporous TiO2/calcium-phosphate coating on Ti doped with strontium, cobalt and fluorine (SCF-TiCP) was developed, which had a hierarchical micro/nanostructure with a microporous structure evenly covered with nano-grains. SCF-TiCP greatly inhibited the colonization and growth of both gram-positive and gram-negative bacteria. No cytotoxicity appeared for SCF-TiCP. Furthermore, SCF-TiCP stimulated the expression of key angiogenic factors in rat bone marrow stem cells (MSCs) and dramatically enhanced MSC osteogenic differentiation. The in vivo animal test displayed that SCF-TiCP induced more new bone and tighter implant/bone bonding. In conclusion, multifunction SCF-TiCP of antibacterial, angiogenic and osteogenic activities is a promising orthopedic and dental Ti implant coating for improved clinical performance.

引用

页数：14

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