Large stabilization of a DNA duplex by the deoxyadenosine derivatives tethering an aromatic hydrocarbon group

被引：32

作者：

Nakano, S

Uotani, Y

Nakashima, S

Anno, Y

Fujii, M

Sugimoto, N

机构：

[1] Konan Univ, High Technol Res Ctr, Higashinada Ku, Kobe, Hyogo 6588501, Japan

[2] Konan Univ, Fac Sci & Engn, Dept Chem, Higashinada Ku, Kobe, Hyogo 6588501, Japan

[3] Kinki Univ, Kyushu Sch Engn, Iizuka, Fukuoka 8208555, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 27期

关键词：

D O I：

10.1021/ja034465b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel deoxyadenosine derivatives tethering a phenyl or naphthyl group by means of an amido linker have been synthesized, and these derivatives, stacking on the 5′ end of a DNA duplex, provide free energy contributions equal to or greater than that of the Watson-Crick A/T base pair. Copyright © 2003 American Chemical Society.

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页码：8086 / 8087

页数：2

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