Hidden Markov models

被引：887

作者：

Eddy, SR

机构：

[1] Department of Genetics, Washington Univ. School of Medicine, Box 8232, St. Louis, MO 63110

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 03期

关键词：

D O I：

10.1016/S0959-440X(96)80056-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

'Profiles' of protein structures and sequence alignments can detect subtle homologies. Profile analysis has been put on firmer mathematical ground by the introduction of hidden Markov model (HMM) methods. During the past year, applications of these powerful new HMM-based profiles have begun to appear in the fields of protein-structure prediction and large-scale genome-sequence analysis.

引用

页码：361 / 365

页数：5

共 32 条

[1] THE POSTERIOR PROBABILITY-DISTRIBUTION OF ALIGNMENTS AND ITS APPLICATION TO PARAMETER-ESTIMATION OF EVOLUTIONARY TREES AND TO OPTIMIZATION OF MULTIPLE ALIGNMENTS
ALLISON, L
WALLACE, CS
[J]. JOURNAL OF MOLECULAR EVOLUTION, 1994, 39 (04) : 418 - 430
[2] ISSUES IN SEARCHING MOLECULAR SEQUENCE DATABASES
ALTSCHUL, SF
BOGUSKI, MS
GISH, W
WOOTTON, JC
[J]. NATURE GENETICS, 1994, 6 (02) : 119 - 129
[3] ASAI K, 1993, COMPUT APPL BIOSCI, V9, P141
[4] SMOOTH ONLINE LEARNING ALGORITHMS FOR HIDDEN MARKOV-MODELS
BALDI, P
CHAUVIN, Y
[J]. NEURAL COMPUTATION, 1994, 6 (02) : 307 - 318
[5] HIDDEN MARKOV-MODELS OF BIOLOGICAL PRIMARY SEQUENCE INFORMATION
BALDI, P
CHAUVIN, Y
HUNKAPILLER, T
MCCLURE, MA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (03) : 1059 - 1063
[6] Baldi P, 1995, J Comput Biol, V2, P487, DOI 10.1089/cmb.1995.2.487
[7] BARTON GJ, 1990, METHOD ENZYMOL, V183, P403
[8] PREDICTING COILED COILS BY USE SF PAIRWISE RESIDUE CORRELATIONS
BERGER, B
WILSON, DB
WOLF, E
TONCHEV, T
MILLA, M
KIM, PS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (18) : 8259 - 8263
[9] A METHOD TO IDENTIFY PROTEIN SEQUENCES THAT FOLD INTO A KNOWN 3-DIMENSIONAL STRUCTURE
BOWIE, JU
LUTHY, R
EISENBERG, D
[J]. SCIENCE, 1991, 253 (5016) : 164 - 170
[10] BROWN M, 1993, 1ST P INT C INT SYST, P47

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