Is NF-κB a culprit in type 2 diabetes?

被引：25

作者：

Chen, F ^{[1
]}

机构：

[1] NIOSH, Hlth Effects Lab Div, Morgantown, WV 26505 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 332卷 / 01期

关键词：

IKK beta; NNF-kappa B; insulin resistance; diabetes;

D O I：

10.1016/j.bbrc.2005.03.075

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappa B signaling. Earlier studies indicated that IKK beta was the key for the development of insulin resistance. However, it was unknown whether IKK beta itself, or its downstream target, NF-kappa B, plays major roles in insulin resistance. New data suggest that NF-kappa B and NF-kappa B-regulated cytokines are crucial for the diabetogenesis. Published by Elsevier Inc.

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页码：1 / 3

页数：3

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