WASP-interacting protein (WIP):: working in polymerisation and much more

被引：68

作者：

Anton, Ines M. ^{[1
]}

Jones, Gareth E. ^{[2
]}

Wandosell, Francisco ^{[1
]}

Geha, Raif ^{[3
]}

Ramesh, Narayanaswamy ^{[3
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[2] Kings Coll London, Randall Div Cell & Mol Biophys, London SE1 1UL, England

[3] Harvard Univ, Sch Med, Childrens Hosp, Div Immunol, Boston, MA 02115 USA

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tcb.2007.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The migration of cells and the movement of some intracellular pathogens, such as Shigella and Vaccinia, are dependent on the actin-based cytoskeleton. Many proteins are involved in regulating the dynamics of the actin-based microfilaments within cells and, among them, WASP and N-WASP have a significant role in the regulation of actin polymerisation. The activity and stability of WASP is regulated by its cellular partner WASP-interacting protein (WIP) during the formation of actin-rich structures, including the immune synapse, filopodia, lamellipodia, stress fibres and podosomes. Here, we review the role of WIP in regulating WASP function by stabilising WASP and shuttling WASP to areas of actin assembly in addition to reviewing the WASP-independent functions of WIP.

引用

页码：555 / 562

页数：8

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