Urine Is a Better Biomarker Source Than Blood Especially for Kidney Diseases

被引:24
作者
Gao, Youhe [1 ]
机构
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Natl Key Lab Med Mol Biol, Dept Pathophysiol,Sch Basic Med, Beijing 100730, Peoples R China
来源
URINE PROTEOMICS IN KIDNEY DISEASE BIOMARKER DISCOVERY | 2015年 / 845卷
关键词
Change; Homeostasis; Confounding factors; Animal model; PROTEINS; PLASMA;
D O I
10.1007/978-94-017-9523-4_1
中图分类号
Q [生物科学];
学科分类号
090105 [作物生产系统与生态工程];
摘要
Change is the soul of biomarker definition. Changes are more likely to be removed from blood because of homeostasis mechanisms of the body. Therefore, urine is probably a better biomarker source than blood. The road map to the urinary biomarker era is proposed. Researchers are reminded the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce most significant changes in urine.
引用
收藏
页码:3 / 12
页数:10
相关论文
共 21 条
[1]
Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].
Atkinson, AJ ;
Colburn, WA ;
DeGruttola, VG ;
DeMets, DL ;
Downing, GJ ;
Hoth, DF ;
Oates, JA ;
Peck, CC ;
Schooley, RT ;
Spilker, BA ;
Woodcock, J ;
Zeger, SL .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95
[2]
The Human Urine Metabolome [J].
Bouatra, Souhaila ;
Aziat, Farid ;
Mandal, Rupasri ;
Guo, An Chi ;
Wilson, Michael R. ;
Knox, Craig ;
Bjorndahl, Trent C. ;
Krishnamurthy, Ramanarayan ;
Saleem, Fozia ;
Liu, Philip ;
Dame, Zerihun T. ;
Poelzer, Jenna ;
Huynh, Jessica ;
Yallou, Faizath S. ;
Psychogios, Nick ;
Dong, Edison ;
Bogumil, Ralf ;
Roehring, Cornelia ;
Wishart, David S. .
PLOS ONE, 2013, 8 (09)
[3]
Using enrichment index for quality control of secretory protein sample and identification of secretory proteins [J].
Chen, Yong ;
Gu, Bei ;
Wu, Shuzhen ;
Sun, Wei ;
Ma, Sucan ;
Liu, Yuqin ;
Gao, Youhe .
JOURNAL OF MASS SPECTROMETRY, 2009, 44 (03) :397-403
[4]
Gao Y, 2014, BIOINFORMATICS, V1, P00005, DOI DOI 10.15406/MOJPB.2014.01.00005
[5]
Gao Y, 2014, BIOINFORMATICS, V1, P00003
[6]
Urine-an untapped goldmine for biomarker discovery? [J].
Gao YouHe .
SCIENCE CHINA-LIFE SCIENCES, 2013, 56 (12) :1145-1146
[7]
Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease [J].
Huang, Jeffrey T-J ;
Chaudhuri, Rekha ;
Albarbarawi, Osama ;
Barton, Alun ;
Grierson, Christal ;
Rauchhaus, Petra ;
Weir, Christopher J. ;
Messow, Martina ;
Stevens, Nicola ;
McSharry, Charles ;
Feuerstein, Giora ;
Mukhopadhyay, Somnath ;
Brady, Jeffrey ;
Palmer, Colin N. A. ;
Miller, Douglas ;
Thomson, Neil C. .
THORAX, 2012, 67 (06) :502-508
[8]
IPCS, 2001, BIOM RISK ASS VAL VA, V22
[9]
Urimem, a membrane that can store urinary proteins simply and economically, makes the large-scale storage of clinical samples possible [J].
Jia LuLu ;
Liu XueJiao ;
Liu Liu ;
Li MingXi ;
Gao YouHe .
SCIENCE CHINA-LIFE SCIENCES, 2014, 57 (03) :336-339
[10]
An Attempt to Understand Kidney's Protein Handling Function by Comparing Plasma and Urine Proteomes [J].
Jia, Lulu ;
Zhang, Ling ;
Shao, Chen ;
Song, Eli ;
Sun, Wei ;
Li, Mingxi ;
Gao, Youhe .
PLOS ONE, 2009, 4 (04)