Successful haploidentical bone marrow transplantation in Fanconi anemia

被引：14

作者：

Elhasid, R

Ben Arush, MW

Katz, T

Gan, Y

Shechter, Y

Sami, I

Postovsky, S

Reisner, Y

Rowe, JM

机构：

[1] Rambam Med Ctr, Dept Pediat Hematooncol, IL-31096 Haifa, Israel

[2] Rambam Med Ctr, Dept Hematol, IL-31096 Haifa, Israel

[3] Rambam Med Ctr, Dept Immunol, IL-31096 Haifa, Israel

[4] Technion Israel Inst Technol, Haifa, Israel

[5] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 11期

关键词：

Fanconi anemia; haploidentical bone marrow transplantation;

D O I：

10.1038/sj.bmt.1702701

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available.

引用

页码：1221 / 1223

页数：3

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