Estrogen and ERα: Culprits in cervical cancer?

被引：188

作者：

Chung, Sang-Hyuk ^{[1
]}

Franceschi, Silvia ^{[2
]}

Lambert, Paul F. ^{[1
]}

机构：

[1] Univ Wisconsin, McArdle Lab Canc Res, Sch Med & Publ Hlth, Madison, WI 53706 USA

[2] Int Agcy Res Canc, F-69372 Lyon 08, France

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 08期

关键词：

HUMAN-PAPILLOMAVIRUS TYPE-16; BREAST-CANCER; POSTMENOPAUSAL WOMEN; EXOGENOUS ESTROGEN; NATURAL-HISTORY; GENE-EXPRESSION; RISK-FACTORS; CELL-GROWTH; MOUSE MODEL; TAMOXIFEN;

D O I：

10.1016/j.tem.2010.03.005

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Estrogen and its receptors are implicated in the promotion and prevention of various cancers. Although the uterine cervix is highly responsive to estrogen, the role of estrogen in cervical cancer, which is strongly associated with human papillomavirus (HPV) infections, is poorly understood. Recent studies in HPV transgenic mouse models provide evidence that estrogen and its nuclear receptor promote cervical cancer in combination with HPV oncogenes. Although epidemiological studies further support this hypothesis, there is little experimental data assessing the hormonal responsiveness of human cervical cancers. If these cancers are dependent on estrogen, then drugs targeting estrogen and its receptors could be effective in treating and/or preventing cervical cancer, the second leading cause of death by cancer among women worldwide.

引用

页码：504 / 511

页数：8

共 66 条

[1]

Molecular targets and anticancer potential of indole-3-carbinol and its derivatives [J].

Aggarwal, BB ;

Ichikawa, H .

CELL CYCLE, 2005, 4 (09) :1201-1215

[2]

Cervical carcinoma and reproductive factors:: Collaborative reanalysis of individual data on 16,563 women with cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemiological studies [J].

Appleby, P. ;

Beral, V. ;

de Gonzalez, A. Berrington ;

Colin, D. ;

Franceschi, S. ;

Green, J. ;

La Vecchia, C. ;

Peto, J. ;

Plummer, M. ;

Randi, G. ;

Sweetland, S. .

INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (05) :1108-1124

[3]

Appleby P, 2007, LANCET, V370, P1609, DOI 10.1016/S0140-6736(07)61684-5

[4]

Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice [J].

Arbeit, JM ;

Howley, PM ;

Hanahan, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (07) :2930-2935

[5]

Human papillomavirus E7 oncoprotein dysregulates steroid receptor coactivator 1 localization and function [J].

Baldwin, Amy ;

Huh, Kyung-Won ;

Munger, Karl .

JOURNAL OF VIROLOGY, 2006, 80 (13) :6669-6677

[6]

Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis [J].

Balsitis, Scott ;

Dick, Fred ;

Dyson, Nicholas ;

Lambert, Paul F. .

CANCER RESEARCH, 2006, 66 (19) :9393-9400

[7]

Placebo-controlled trial of indole-3-carbinol in the treatment of CIN [J].

Bell, MC ;

Crowley-Nowick, P ;

Bradlow, HL ;

Sepkovic, DW ;

Schmidt-Grimminger, D ;

Howell, P ;

Mayeaux, EJ ;

Tucker, A ;

Turbat-Herrera, EA ;

Mathis, JM .

GYNECOLOGIC ONCOLOGY, 2000, 78 (02) :123-129

[8]

Evaluation of tamoxifen in persistent or recurrent nonsquamous cell carcinoma of the cervix: a Gynecologic Oncology Group study [J].

Bigler, LR ;

Thigpen, JT ;

Blessing, JA ;

Fiorica, J ;

Monk, BJ .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2004, 14 (05) :871-874

[9]

Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a human papillomavirus-transgenic mouse model [J].

Brake, T ;

Lambert, PF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (07) :2490-2495

[10]

Brake T, 2003, CANCER RES, V63, P8173

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