The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a review

被引：106

作者：

Krieckaert, Charlotte Louise Maria ^{[1
]}

Bartelds, Geertje Margret ^{[1
]}

Lems, Willem Frederik ^{[2
]}

Wolbink, Gerrit Jan ^{[1
]}

机构：

[1] Jan van Breemen Inst, Dept Rheumatol, NL-1056 AB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Rheumatol, NL-1007 MB Amsterdam, Netherlands

来源：

ARTHRITIS RESEARCH & THERAPY | 2010年 / 12卷 / 05期

关键词：

RHEUMATOID-ARTHRITIS PATIENTS; DECREASED CLINICAL-RESPONSE; ANTI-ADALIMUMAB ANTIBODIES; CROHNS-DISEASE; ANKYLOSING-SPONDYLITIS; MAINTENANCE INFLIXIMAB; METHOTREXATE; COMBINATION; EFFICACY;

D O I：

10.1186/ar3147

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Therapeutic monoclonal antibodies have revolutionized the treatment of various inflammatory diseases. Immunogenicity against these antibodies has been shown to be clinically important: it is associated with shorter response duration because of diminishing concentrations in the blood and with infusion reactions. Concomitant immunomodulators in the form of methotrexate or azathioprine reduced the immunogenicity of therapeutic antibodies in rheumatoid arthritis, Crohn disease, and juvenile idiopathic arthritis. The occurrence of adverse events does not increase when immunomodulators are added to therapeutic antibodies. The mechanism whereby methotrexate and azathioprine influence immunogenicity remains unclear. Evidence-based consensus on prescribing concomitant immunomodulators is needed.

引用

页数：6

共 31 条

[1]

Immunogenicity of Anti-TNF-α Agents in Autoimmune Diseases [J].

Aikawa, Nadia Emi ;

de Carvalho, Jozelio Freire ;

Almeida Silva, Clovis Artur ;

Bonfa, Eloisa .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2010, 38 (2-3) :82-89

[2]

Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease [J].

Baert, F ;

Noman, M ;

Vermeire, S ;

Van Assche, G ;

D'Haens, G ;

Carbonez, A ;

Rutgeerts, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (07) :601-608

[3]

Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis [J].

Bartelds, Geertje M. ;

Wijbrandts, Carla A. ;

Nurmohamed, Michael T. ;

Stapel, Steven ;

Lems, Willem F. ;

Aarden, Lucien ;

Dijkmans, Ben A. C. ;

Tak, Paul Peter ;

Wolbink, Gerrit Jan .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (07) :921-926

[4]

Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor α inhibitor infliximab [J].

Bendtzen, Klaus ;

Geborek, Pierre ;

Svenson, Morten ;

Larsson, Lotta ;

Kapetanovic, Meliha C. ;

Saxne, Tore .

ARTHRITIS AND RHEUMATISM, 2006, 54 (12) :3782-3789

[5]

Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice:: the Research in Active Rheumatoid Arthritis (ReAct) trial [J].

Burmester, Gerd R. ;

Mariette, Xavier ;

Montecucco, Carlomaurizio ;

Monteagudo-Saez, Indalecio ;

Malaise, Michel ;

Tzioufas, Athanasios G. ;

Bijlsma, Johannes W. J. ;

Unnebrink, Kristina ;

Kary, Sonja ;

Kupper, Hartmut .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (06) :732-739

[6]

Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease. [J].

Colombel, Jean Frederic ;

Sandborn, William J. ;

Reinisch, Walter ;

Mantzaris, Gerassimos J. ;

Kornbluth, Asher ;

Rachmilewitz, Daniel ;

Lichtiger, Simon ;

D'Haens, Geert ;

Diamond, Robert H. ;

Broussard, Delma L. ;

Tang, Kezhen L. ;

van der Woude, C. Janneke ;

Rutgeerts, Paul .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (15) :1383-1395

[7]

Decreased clinical response to adalimumab in ankylosing spondylitis is associated with antibody formation [J].

de Vries, M. K. ;

Brouwer, E. ;

van der Horst-Bruinsma, I. E. ;

Spoorenberg, A. ;

van Denderen, J. C. ;

Jamnitski, A. ;

Nurmohamed, M. T. ;

Dijkmans, B. A. C. ;

Aarden, L. A. ;

Wolbink, G. J. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (11) :1787-1788

[8]

Decreased clinical response to infliximab in ankylosing spondylitis is correlated with anti-infliximab formation [J].

de Vries, Mirjam K. ;

Wolbink, Gerrit Jan ;

Stapel, Steven O. ;

de Vrieze, Henk ;

van denderen, J. Christiaan ;

Dijkmans, Ben A. C. ;

Aarden, Lucien A. ;

van der Horst-Bruinsma, Irene E. .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (09) :1252-1254

[9]

A systematic medline analysis of therapeutic approaches in ankylosing spondylitis [J].

Goh, L. ;

Samanta, A. .

RHEUMATOLOGY INTERNATIONAL, 2009, 29 (10) :1123-1135

[10]

Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial [J].

Hanauer, SB ;

Sandborn, WJ ;

Rutgeerts, P ;

Fedorak, RN ;

Lukas, M ;

Macintosh, D ;

Panaccione, R ;

Wolf, D ;

Pollack, P .

GASTROENTEROLOGY, 2006, 130 (02) :323-332

← 1 2 3 4 →