Hyperalgesia in mice lacking the Kv1.1 potassium channel gene

被引：50

作者：

Clark, JD

Tempel, BL

机构：

[1] Univ Washington, Sch Med, Dept Head & Neck Surg, Seattle, WA 98195 USA

[2] Virginia Merrill Bloedel Hearing Res Ctr, Dept Anesthesiol & Otolaryngol, Seattle, WA 98195 USA

来源：

NEUROSCIENCE LETTERS | 1998年 / 251卷 / 02期

关键词：

potassium channels; morphine; hyperalgesia; null mutant; Kv1.1;

D O I：

10.1016/S0304-3940(98)00516-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hyperalgesia and morphine induced antinociception were measured in mice lacking the gene for the Shaker-like voltage-gated potassium channel Kv1.1 alpha subunit. The effects of varying gene dosage were studied by comparing homozygous null (-/-) versus heterozygous (+/-) and wildtype (+/+) littermates. Hyperalgesia was measured using the paw flick assay, hot plate assay and formalin induced hind paw licking. It was observed thar null mutant animals had significantly shorter latencies to response in the paw flick (36%) and hot plate (27%) assays while their licking times after hind paw injection of formalin was increased in both the first (74%) and second (65%) phases of the response compared to wildtype controls. Morphine induced antinociception in Kv1.1 null mutant animals was blunted. These studies indicate that Kv1.1 plays an important role in nociceptive and antinociceptive signaling pathways. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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页码：121 / 124

页数：4

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