Studies of structure activity relationship of flavonoids for the anti-allergic actions

被引：120

作者：

Cheong, H

Ryu, SY

Oak, MH

Cheon, SH

Yoo, GS

Kim, KM ^{[1
]}

机构：

[1] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305606, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 04期

关键词：

allergy; flavonoids; degranulation; hexosaminidase;

D O I：

10.1007/BF02974647

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 mu M.

引用

页码：478 / 480

页数：3

共 11 条

[1]

Choi OH, 1996, NATURE, V380, P634

[2] QUERCETIN INHIBITS ANAPHYLACTIC CONTRACTION OF GUINEA-PIG ILEUM SMOOTH-MUSCLE [J].