Akt takes centre stage in cell-cycle deregulation

被引：42

作者：

El-Deiry, WS

机构：

[1] Univ Penn, Sch Med, Howard Hughes Med Inst, Dept Med,Lab Mol Oncol & Cell Cycle Regulat, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Howard Hughes Med Inst, Dept Genet,Lab Mol Oncol & Cell Cycle Regulat, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Lab Mol Oncol & Cell Cycle Regulat, Philadelphia, PA 19104 USA

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 03期

关键词：

D O I：

10.1038/35060148

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The universal cell-cycle inhibitor p21(Cip1/WAF1) is phosphorylated and localized in the cytoplasm in Her2/neu-overexpressing breast cancers as a result of its physical association with the oncogenic Akt protein. Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation in cancer.

引用

页码：E71 / E73

页数：3

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