Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: association of decreased plasminogen activator inhibitor 2 with lymph node metastasis

被引:43
作者
Yoshino, H
Endo, Y
Watanabe, Y
Sasaki, T
机构
[1] Kanazawa Univ, Canc Res Inst, Dept Expt Therapeut & Dev Ctr Mol Target Drugs, Kanazawa, Ishikawa 920, Japan
[2] Kanazawa Univ, Sch Med, Dept Surg 1, Kanazawa, Ishikawa 920, Japan
关键词
prognosis; lung cancer; lymph node metastasis; plasminogen activator inhibitor 2;
D O I
10.1038/bjc.1998.588
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The expression of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitor (PAI) 1 and 2 was examined in 105 cases of primary lung cancer tissue using immunohistochemical staining and reverse transcriptase polymerase chain reaction (RT-PCR) techniques. The expression of u-PA, u-PAR and PAI-1 was detected in approximately 80% of primary lung cancers, whereas detectable PAI-2 expression was observed only in half of the overall cases. We assessed the relationships between the expression pattern and clinicopathological findings and found that a diminished expression level of PAI-2 was significantly correlated with lymph node metastasis and a poor prognosis. These results indicate that PAI-2 may play a critical role in the regulation of extracellular matrix degradation during tumour cell invasion and metastasis, and the expression of PAI-e may be useful as a marker for evaluating the prognosis of lung cancer.
引用
收藏
页码:833 / 839
页数:7
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