Increased plasma levels of phthalate esters in women with advanced-stage endometriosis: a prospective case-control study

被引:98
作者
Kim, Sung Hoon [1 ]
Chun, Sail [2 ]
Jang, Jin Yeon [2 ]
Chae, Hee Dong [1 ]
Kim, Chung-Hoon [1 ]
Kang, Byung Moon [1 ]
机构
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Obstet & Gynecol, Seoul 138736, South Korea
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Lab Med, Seoul 138736, South Korea
关键词
Phthalate; endocrine disruptor; endometriosis; pathogenesis; TANDEM MASS-SPECTROMETRY; QUANTITATIVE DETECTION; HUMAN EXPOSURE; BODY-SIZE; METABOLITES; ASSOCIATION; BIOMARKERS; HUMANS;
D O I
10.1016/j.fertnstert.2010.07.1059
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
We performed the present prospective case-control study to evaluate whether the plasma concentrations of phthalate esters are elevated in women with advanced-stage endometriosis in a Korean population. Measuring plasma levels of monoethylhexyl phthalate and di-(2-ethylhexyl) phthalate in 97 women with advanced-stage endometriosis and 169 control women by liquid chromatography-tandem mass spectrometry, we found that the concentrations of monoethylhexyl phthalate, as well as di-(2-ethylhexyl) phthalate, are significantly higher in those with advanced-stage endometriosis, which supports the hypothesis that exposure to phthalate might play a role in the establishment of endometriosis. (Fertil Steril (R) 2011; 95: 357-9. (c) 2011 by American Society for Reproductive Medicine.)
引用
收藏
页码:357 / 359
页数:3
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