Increased plasma levels of phthalate esters in women with advanced-stage endometriosis: a prospective case-control study

被引：98

作者：

Kim, Sung Hoon ^{[1
]}

Chun, Sail ^{[2
]}

Jang, Jin Yeon ^{[2
]}

Chae, Hee Dong ^{[1
]}

Kim, Chung-Hoon ^{[1
]}

Kang, Byung Moon ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Obstet & Gynecol, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Lab Med, Seoul 138736, South Korea

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 01期

关键词：

Phthalate; endocrine disruptor; endometriosis; pathogenesis; TANDEM MASS-SPECTROMETRY; QUANTITATIVE DETECTION; HUMAN EXPOSURE; BODY-SIZE; METABOLITES; ASSOCIATION; BIOMARKERS; HUMANS;

D O I：

10.1016/j.fertnstert.2010.07.1059

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

We performed the present prospective case-control study to evaluate whether the plasma concentrations of phthalate esters are elevated in women with advanced-stage endometriosis in a Korean population. Measuring plasma levels of monoethylhexyl phthalate and di-(2-ethylhexyl) phthalate in 97 women with advanced-stage endometriosis and 169 control women by liquid chromatography-tandem mass spectrometry, we found that the concentrations of monoethylhexyl phthalate, as well as di-(2-ethylhexyl) phthalate, are significantly higher in those with advanced-stage endometriosis, which supports the hypothesis that exposure to phthalate might play a role in the establishment of endometriosis. (Fertil Steril (R) 2011; 95: 357-9. (c) 2011 by American Society for Reproductive Medicine.)

引用

页码：357 / 359

页数：3

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