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Retinoid nutritional status differently affects the expression of Japanese quail retinoic acid receptor-β isoform transcripts in a tissue-specific manner

被引：7
作者：
Fu, ZW
Kubo, T
Sugahara, K
Noguchi, T
Kato, H [1 ]
机构：
[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Lab Nutrit Biochem,Bunkyo Ku, Tokyo 1138657, Japan
[2] Utsunomiya Univ, Fac Agr, Utsunomiya, Tochigi 3218505, Japan
来源：
JOURNAL OF ENDOCRINOLOGY | 2001年 / 169卷 / 02期
关键词：
D O I：
10.1677/joe.0.1690281
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the effects of vitamin A (VA) nutritional status on the levels of expression of retinoic acid (RA) receptor-beta (RAR beta) gene in the various tissues of Japanese quail. VA deficiency caused a significant decrease in the mRNA levels of brain, liver, heart, lung and kidney RAR beta2/beta4, whereas no change was observed in the level of testis RAR beta2 transcript. In contrast, reduction in the RAR beta1 transcript caused by VA depletion was observed only in the lung, remaining unchanged in the other tissues. The administration of RA to the VA-deficient quail rapidly induced the expression of RAR beta2/beta4 mRNAs in all the tissues examined, but RA increased the expression of RAR beta1 transcript in the liver, heart, lung and kidney at a lower magnitude. RA could not change the expression of the brain RAR beta1 transcript, while it induced the expression of the testis RAR beta1 mRNA in a temporal way. These results clearly indicate that VA nutritional status differently regulates the expression of RAR beta1 RAR beta2/beta4 transcripts in a tissue-specific manner.
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收藏
页码：281 / 290
页数：10
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