Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models

被引：50

作者：

Lim, Sang Kyun ^{[1
]}

Llaguno, Sheila R. Alcantara ^{[1
]}

McKay, Renee M. ^{[1
]}

Parada, Luis F. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA

[2] Amer Canc Soc, Atlanta, GA 30329 USA

来源：

BMB REPORTS | 2011年 / 44卷 / 03期

关键词：

Glioblastoma; Glioma; Glioma stem cells; Mouse models of glioma; HEMATOPOIETIC STEM-CELLS; INTEGRATED GENOMIC ANALYSIS; IDENTIFICATION; GLIOMA; MUTATIONS; DIFFERENTIATION; IDH1; TRANSFORMATION; GENERATION; POPULATION;

D O I：

10.5483/BMBRep.2011.44.3.158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Gliomas are the most frequently occurring primary malignancies in the central nervous system, and glioblastoma multiforme (GBM) is the most common and most aggressive of these tumors. Despite vigorous basic and clinical studies over past decades, the median survival of patients with this disease remains at about one year. Recent studies have suggested that GBMs contain a subpopulation of tumor cells that displays stem cell characteristics and could therefore be responsible for in vivo tumor growth. We will summarize the major oncogenic pathways abnormally regulated in gliomas, and review the recent findings from mouse models that our laboratory as well as others have developed for the study of GBM. The concept of cancer stem cells in GBM and their potential therapeutic importance will also be discussed. [BMB reports 2011; 44(3): 158-164]

引用

页码：158 / 164

页数：7

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